The preparation and properties of adenylosuccinase and adenylosuccinic acid.
نویسندگان
چکیده
This reaction is analogous to the aspartase reaction and to the enzymic condensation of arginine and fumaric acid (2). In this paper a more detailed characterization of the adenylosuccinase reaction and the product of the reaction, adenylosuccinic acid, is reported. A synthesis of the aglycone of adenylosuccinic acid, 6-succinoaminopurine, from aspartic acid and 6chloropurine, which confirms the structure proposed for adenylosuccinic acid, is described in another paper.’
منابع مشابه
Studies of the action of adenylosuccinase with 6-thio analogues of adenylosuccinic acid.
Recent work has shown that certain growth inhibitory purine analogues undergo anabolism to ribonucleoside 5’-phosphates (1, 2). Ribonucleoside 5’-phosphate derivatives of purine analogues that effect temporary remission of some human leukemias have been synthesized (3-6), and effects of these nucleotides on enzymatic interconversions of naturally occurring purine nucleotides have been studied (...
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 222 1 شماره
صفحات -
تاریخ انتشار 1956